@article{a3ba79248cba4f609d1b1e27b9f2083c,
title = "Br{\o}nsted Acid-Catalyzed Hydroamination of N-Heterocycles to Unactivated Alkenes",
abstract = "A Br{\o}nsted acid-catalyzed hydroamination of unactivated olefins has been developed, enabling the efficient Markovnikov addition of nitrogen heterocycles to olefins. This reaction utilizes a catalytic amount of trifluoroacetic acid (TFA) to produce a diverse array of N-alkyl nitrogen heterocycles. The method is highly scalable, allowing for multigram synthesis, and a novel proton transfer species implicated in olefin activation has been identified.",
keywords = "Acid catalysis, Markovnikov addition, Metal-free, N-heterocycles, Unactivated alkenes",
author = "Guanzheng Feng and Yisan Shen and Chenghui Sun and Weixiao Ji and He Huang and Siping Pang",
note = "Publisher Copyright: {\textcopyright} 2025 Wiley-VCH GmbH.",
year = "2025",
doi = "10.1002/ajoc.202500579",
language = "English",
journal = "Asian Journal of Organic Chemistry",
issn = "2193-5807",
publisher = "Wiley - VCH Verlag GmbH \& CO. KGaA",
}