Reaction-free mitochondrial membrane potential independent luminogens with aggregation-induced emission characteristics for live neuron imaging

Hojeong Park; Guangle Niu; Alex Y.H. Wong; Eric Y. Yu; Ryan T.K. Kwok; Ben Zhong Tang

doi:10.1039/d4cc06022a

Reaction-free mitochondrial membrane potential independent luminogens with aggregation-induced emission characteristics for live neuron imaging

Hojeong Park, Guangle Niu, Alex Y.H. Wong, Eric Y. Yu, Ryan T.K. Kwok, Ben Zhong Tang^*

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

We developed novel photostable mitochondria targeting probes based on aggregation-induced emission (AIE) luminogens with a cyanostilbene core. The introduction of an alkyl chain onto the pyridinium moiety enhanced their interaction with the mitochondrial membrane. This design effectively prevents probe leakage following mitochondrial membrane depolarization while significantly reducing cytotoxicity.

Original language	English
Pages (from-to)	3536-3539
Number of pages	4
Journal	Chemical Communications
Volume	61
Issue number	17
DOIs	http://doi.org/10.1039/d4cc06022a
Publication status	Published - 30 Jan 2025

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title = "Reaction-free mitochondrial membrane potential independent luminogens with aggregation-induced emission characteristics for live neuron imaging",

abstract = "We developed novel photostable mitochondria targeting probes based on aggregation-induced emission (AIE) luminogens with a cyanostilbene core. The introduction of an alkyl chain onto the pyridinium moiety enhanced their interaction with the mitochondrial membrane. This design effectively prevents probe leakage following mitochondrial membrane depolarization while significantly reducing cytotoxicity.",

author = "Hojeong Park and Guangle Niu and Wong, \{Alex Y.H.\} and Yu, \{Eric Y.\} and Kwok, \{Ryan T.K.\} and Tang, \{Ben Zhong\}",

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AU - Park, Hojeong

AU - Niu, Guangle

AU - Wong, Alex Y.H.

AU - Yu, Eric Y.

AU - Kwok, Ryan T.K.

AU - Tang, Ben Zhong

PY - 2025/1/30

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N2 - We developed novel photostable mitochondria targeting probes based on aggregation-induced emission (AIE) luminogens with a cyanostilbene core. The introduction of an alkyl chain onto the pyridinium moiety enhanced their interaction with the mitochondrial membrane. This design effectively prevents probe leakage following mitochondrial membrane depolarization while significantly reducing cytotoxicity.

AB - We developed novel photostable mitochondria targeting probes based on aggregation-induced emission (AIE) luminogens with a cyanostilbene core. The introduction of an alkyl chain onto the pyridinium moiety enhanced their interaction with the mitochondrial membrane. This design effectively prevents probe leakage following mitochondrial membrane depolarization while significantly reducing cytotoxicity.

UR - http://www.scopus.com/pages/publications/85217523069

U2 - 10.1039/d4cc06022a

DO - 10.1039/d4cc06022a

M3 - Article

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VL - 61

SP - 3536

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JO - Chemical Communications

JF - Chemical Communications

IS - 17

ER -

Reaction-free mitochondrial membrane potential independent luminogens with aggregation-induced emission characteristics for live neuron imaging

Abstract

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